Essential Role of Osterix for Tooth Root but not Crown Dentin Formation
نویسندگان
چکیده
منابع مشابه
Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation
Dental root formation is a dynamic process in which mesenchymal cells migrate toward the site of the future root, differentiate and secrete dentin and cementum. However, the identities of dental mesenchymal progenitors are largely unknown. Here we show that cells expressing osterix are mesenchymal progenitors contributing to all relevant cell types during morphogenesis. The majority of cells ex...
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Osterix (Osx) is an osteoblast-specific transcription factor that is essential for bone formation. MicroRNAs (miRNAs) are ~22-nucleotide-long noncoding RNAs that play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. They can also control osteoblast-mediated bone formation and osteoclast-related bone remodeling. The vital roles of Osx ...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2015
ISSN: 0884-0431
DOI: 10.1002/jbmr.2391